Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

Xi'an Jiaotong University

Status: Completed

Conditions: Liver Transplantation; Survival; Hepatocellular Carcinoma

Treatments: Other: Age

Study type: Observational

Funder types: Other

Identifiers

NCT05355662

No. XJTU1AF-CRF-2019-029

Details and patient eligibility

About

Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Full description

Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Enrollment: 11,569 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Recipient age ≥ 18 years and < 65 years.
2. Donor age ≥ 18 years.

Exclusion criteria

1. Recipient age <18 years or ≥65 years.
2. Donor age <18 years.
3. Patients who died within 30 days after transplantation.
4. Secondary liver transplantation.
5. Multiple organ transplantation.
6. Patients with incomplete data or failed follow-up.

Trial design

11,569 participants in 3 patient groups

OLDs

Description:

Older liver donors (OLDs) and recipients were defined as individuals whose donor age was equal to or greater than 60 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Treatment:

Other: Age

ILDs

Description:

Ideal or young liver donors (ILDs) and recipients were defined as donors aged 18-40 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Treatment:

Other: Age

ALDs

Description:

Average liver donors (ALDs) and recipients were defined as donor age 40-59 years. Subjects matching the characteristics of this group were screened from the database according to inclusion and exclusion criteria, and preoperative and postoperative characteristics of the corresponding recipients and donors were collected and recorded for subsequent analysis.

Treatment:

Other: Age