Prognosis and Risk Factors for Acute Kidney Injury

Seoul National University

Status: Enrolling

Conditions: Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06898944

H-2208-015-1347

Details and patient eligibility

About

The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes.

Investigators defined the AKI group among adults aged 20 years or older who visited enrolled center and underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less and a control group was matched 1:1 to the AKI group based on age, sex, year of visit, and baseline kidney function, forming the study population. Investigators then collected and analyzed various clinical, laboratory, and hospitalization records including demographic data, anthropometric data, laboratory data, and medical history.

Enrollment: 320,000 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults over 20 years old who visited Parcitipating Medical Center (Seoul National University Hospital, Bundang Seoul National University Hospital, SMG-SNU Boramae Medical Center, Keimyung University Dongsan Medical Center) between 2006 and 2021
• The AKI group is defined as individuals meeting the AKI diagnostic criteria of the KDIGO Guideline (an increase in serum creatinine of ≥0.3 mg/dL or ≥1.5 times the baseline level) is enrolled.
• The Control Group is defined as individuals from the study population who do not meet the AKI criteria and are matched 1:1 based on age, sex, year of visit, and baseline renal function.

Exclusion criteria

• Individuals under 20 years old
• Individuals who did not undergo serum creatinine tests meeting the criteria
• Individuals with pre-existing end-stage kidney disease (ESKD) who have undergone dialysis or kidney transplantation

Trial design

320,000 participants in 2 patient groups

AKI group

Description:

* Aged 20 years or older who visited hospital * Underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less * AKI was defined based on the KDIGO criteria (an increase in serum creatinine by ≥0.3 mg/dL or ≥1.5 times the baseline).

Control group

Description:

Control group was matched 1:1 to the AKI group based on age, sex, year of visit, and baseline kidney function, forming the study population.