Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study (REACIRRHOSE)

Centre Hospitalier Universitaire de Besancon

Status: Enrolling

Conditions: Cirrhosis; Acute on Chronic Liver Failure(ACLF); Intensive Care Medicine

Treatments: Other: observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06948565

2024/908

Details and patient eligibility

About

Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients.

The following hypotheses will be tested:

• Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014
• Improved access to liver transplantation compared with the literature prior to 2014
• Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.).
• Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.

Enrollment: 500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024.

Exclusion criteria

None