Prognosis Predicting of CRC Patients Based on Morphology and Molecular Biomaker of CTC

Fudan University

Status: Not yet enrolling

Conditions: Circulating Tumor Cell; Colorectal Cancer

Treatments: Diagnostic Test: Circulating tumor cell

Study type: Observational

Funder types: Other

Identifiers

NCT04912882

ZSCTC1

Details and patient eligibility

About

Detecting circulating tumor cells from I-IV stage colorectal cancer patients pre-and post-operatively. Analyzing the morphology and biomarkers of CTCs and builting prognosis predicting model based on the morphology and biomarkers of CTCs. Verifying the prognosis model by the survival data.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80 years;

Histologically proven colorectal carcinoma (TNM stage I-IV)

R0 resection is possible according to preoperative evaluation

Written informed consent for participation in the trial.

Exclusion criteria

• Primary tumor or metastases not able to be removed radically

Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)

Have other malignant tumors meanwhile

Other previous malignancy within 5 years

Trial design

1,000 participants in 2 patient groups

Training Group

Description:

Training group including about 500 patients that be using to building the prognosis model

Treatment:

Diagnostic Test: Circulating tumor cell

Validation Group

Description:

Validation group including about another 500 patients that be using to validating the prognosis model

Treatment:

Diagnostic Test: Circulating tumor cell