Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics (PROSPECT)

Xi'an Jiaotong University

Status: Enrolling

Conditions: Heart Valve Diseases; Coronary Artery Disease; Structural Heart Disease; Ischemic Cerebrovascular Disease; Heart Neoplasms; Arrhythmias, Cardiac; Cardiomyopathies; Aortic Dissection; Hypertension; Myocarditis; Brain Neoplasms; Hemorrhagic Cerebrovascular Disease

Treatments: Other: Observational; No Interventions were given.

Study type: Observational

Funder types: Other

Identifiers

NCT06001073

XJTU1AF2023LSK-353

Details and patient eligibility

About

The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Full description

Cardiovascular and cerebrovascular diseases refer to ischemic and hemorrhagic diseases of the heart, brain and body tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. It is one of the major public health problems in the world. The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Enrollment: 25,000 estimated patients

Sex: All

Ages: 3 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are regularly visited and followed up in the appropriate patient; department.
• All patients met at least one of the following diagnostic criteria for cardiovascular and cerebrovascular diseases:
• coronary artery disease group;
• arrhythmia group;
• heart valve disease group;
• aortic dissection group;
• cardiac masses group;
• myocarditis group;
• hypertension group;
• cardiomyopathy group;
• structural heart disease group;
• ischemic cerebrovascular disease group;
• hemorrhagic cerebrovascular disease group;
• intracranial space occupying lesion group.

Exclusion criteria

• Age <3 years or >80 years old;
• Pregnant and lactating women;
• The patient declined to provide informed consent to participate in the study;
• None of the above was met, but the patient was temporarily unable to sign the informed consent form due to coma and other reasons, and no legal representative signed it instead. Depending on the patient's condition, the patient may not be able to regain consciousness and sign the informed consent form.

Trial design

25,000 participants in 12 patient groups

Coronary artery disease group

Description:

Diagnosis of coronary artery disease by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Arrhythmia group

Description:

Diagnosis of arrhythmia by clinical guidelines. by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Heart valve disease group

Description:

Diagnosis of heart valve disease by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

aortic dissection group

Description:

Diagnosis of aortic dissection by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Cardiac masses group

Description:

Diagnosis of cardiac messes by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Myocarditis group

Description:

Diagnosis of myocarditis by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Hypertension group

Description:

Diagnosis of hypertension by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Cardiomyopathy group

Description:

Diagnosis of cardiomyopathy by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Structural heart disease group

Description:

Diagnosis of structural heart disease by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Ischemic cerebrovascular disease group

Description:

Diagnosis of ischemic cerebrovascular disease by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Hemorrhagic cerebrovascular disease group

Description:

Diagnosis of hemorrhagic cerebrovascular disease by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.

Intracranial space occupying lesion group

Description:

Diagnosis of intracranial space occupying by clinical guidelines.

Treatment:

Other: Observational; No Interventions were given.