Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation (TIH ECMO)

Central Hospital, Nancy, France

Status: Completed

Conditions: Heparin-induced Thrombocytopenia

Treatments: Other: Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies

Study type: Observational

Funder types: Other

Identifiers

NCT03979625

PSS 2016/TIH ECMO-KIMMOUN/SR

Details and patient eligibility

About

Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA
• ECMO-VA duration ≥ 3 days
• HIT confirmed by immunological tests
• Patient affiliated to a Social Security scheme

Exclusion criteria

• Known antecedent of TIH prior to cannulation
• Pregnant woman
• ECMO-VA following cardiopulmonary arrest or septic shock