Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia

Assiut University

Status: Completed

Conditions: Ventilator Associated Pneumonia

Treatments: Diagnostic Test: complete blood picture

Study type: Observational

Funder types: Other

Identifiers

NCT04739748

IRB17300520

Details and patient eligibility

About

The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.

Full description

Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. VAP continues to be a leading cause of morbidity and mortality in the nosocomial setting. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases.

Enrollment: 136 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Respiratory failure needs mechanical ventilator support > 48 hrs. VAP was defined as an acute lower respiratory tract infection in mechanically ventilated patient > 48 hrs with a new or progressing infiltrate on chest radiograph and who met at least two of the following clinical criteria: body temperature >38°C or <36°C with no other recognized cause, white blood cell count >10,000 /mm3 or <5000 /mm3, or a macroscopically purulent tracheal aspirate
• Only the first VAP episode was included

Exclusion criteria

• Neutropenia (< 500 cells/ml) before the development of VAP.
• Conditions are known to influence total and differential WBC counts such as chronic inflammatory conditions, hematologic disorders, history of chemotherapy, or radiotherapy within 4 weeks before enrollment.
• Conditions are known to affect RDW as anemia due to nutritional deficiency (ie, iron, vitamin B12, and folic acid).
• Patients with HIV/AIDS

Trial design

136 participants in 1 patient group

Respiratory ICU patient

Description:

patient in RICU that developed ventilator-associated pneumonia

Treatment:

Diagnostic Test: complete blood picture