Prognostic Impact of Adjuvant Therapy in Primary Hepatic Sarcomatoid Carcinoma

Sichuan University

Status: Enrolling

Conditions: Sarcomatoid Carcinoma; Adjuvant Therapy; Liver Cancer

Treatments: Procedure: postoperative adjuvant therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06950814

JHuang20231

Details and patient eligibility

About

In recent years, researchers have conducted extensive studies on adjuvant therapy following surgical resection of liver cancer, exploring its potential benefits and seeking effective treatment strategies. Given the rarity and high aggressiveness of primary hepatic sarcomatoid carcinoma, there is a lack of reliable clinical evidence on whether postoperative adjuvant therapy can benefit patients, resulting in the absence of established standard guidelines. Therefore, we conducted a single-center retrospective study to assess the potential benefits of postoperative adjuvant therapy for patients of primary hepatic sarcomatoid carcinoma.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients who underwent liver resection
2. patients' postoperative paraffin pathology and immunohistochemistry results were reviewed to identify those diagnosed with PHSC

Exclusion criteria

1. patients who received other anti-tumor treatments before surgery, such as radiofrequency ablation (RFA), transarterial chemoembolization (TACE), radiation therapy (RT), and systemic therapy;
2. patients diagnosed with other specific types of sarcomas;
3. patients with concurrent other malignancies during the course of PHSC;
4. patients who were lost to follow-up or lacked essential clinical data.

Trial design

50 participants in 2 patient groups

Primary hepatic sarcomatoid carcinoma patients who received adjuvant therapy

Treatment:

Procedure: postoperative adjuvant therapy

Primary hepatic sarcomatoid carcinoma patients who did not receive adjuvant therapy