Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients (NCC-HF)

Ospedale Maggiore Di Trieste

Status: Completed

Conditions: Heart Failure, Systolic; Heart Failure, Diastolic

Treatments: Other: prognostic impact of non cardiac comorbidities

Study type: Observational

Funder types: Other

Identifiers

NCT02946476

OMTrieste

Details and patient eligibility

About

To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.

Enrollment: 2,314 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit

Exclusion criteria

• We excluded all patients who had severe primary left-sided valvular disease

Trial design

2,314 participants in 2 patient groups

HFrEF

Description:

patients with heart failure and reduced ejection fraction

Treatment:

Other: prognostic impact of non cardiac comorbidities

HFpEF

Description:

patients with heart failure and preserved ejection fraction

Treatment:

Other: prognostic impact of non cardiac comorbidities