Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease

Cheng-Hsin General Hospital

Status: Enrolling

Conditions: Chronic Kidney Diseases; Biomarker; Acute Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT06006819

CHGH(983)111A-61

Details and patient eligibility

About

Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is one of the most developed prognostic markers for AHR patients and. NT-pro-BNP has limitations in terms of diagnostic or predictive accuracy in patients with chronic kidney disease (CKD). Plasma proteomics have the potential to examine underlying pathophysiological and prognostic roles, so we compared the plasma proteomic signature to predict outcomes of patients with or without CKD hospitalized for AHF.

Enrollment: 155 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hospitalized for acute heart failure

Exclusion criteria

• initial serum NT-proBNP level <300ng/ml, pregnancy, amputated, and end-stage renal disease under regular dialysis