Prognostic Markers of Post-Stroke Depression (PROMoSD)

Ruhr University of Bochum

Status: Enrolling

Conditions: Acute Ischemic Stroke

Treatments: Diagnostic Test: Transcranial sonography.

Study type: Observational

Funder types: Other

Identifiers

NCT05580198

20-6862

Details and patient eligibility

About

Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.

Full description

Post-stroke depression (PSD) is an important complication after a stroke. Despite significant limitations between studies of PSD risk factors, stroke severity or post-stroke disability, prior depressive episodes, and female sex are arguably the most well-known risk factors for developing PSD, although the predictive value of these factors is limited.

A hypoechogenic brainstem raphe (BR) detected by transcranial sonography (TCS) is associated with depressive symptoms in distinct diseases but is also common with approximately 25% of the non-depressed population in Europe. The primary aim of this study is to investigate the association between BR hypoechogenicity and PSD occurrence in a prospective observational study design.

Enrollment: 105 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Acute ischemic stroke with the onset of symptoms within the past 14 days
• Diagnosis of AIS is confirmed by brain imaging, either computer tomography or magnetic resonance imaging

Exclusion criteria

• Insufficient transtemporal bone window for transcranial sonography examination

Trial design

105 participants in 2 patient groups

BRH+

Description:

Acute ischemic stroke patients with brainstem raphe hypoechogenicity.

Treatment:

Diagnostic Test: Transcranial sonography.

BRH-

Description:

Acute ischemic stroke patients without brainstem raphe hypoechogenicity.

Treatment:

Diagnostic Test: Transcranial sonography.