Prognostic Nutritional Index for Predicting Outcomes Following Coronary Artery Bypass Grafting (CABG) Surgery

Benha University

Status: Active, not recruiting

Conditions: Coronary Artery Disease

Treatments: Diagnostic Test: Prognostic Nutritional Index (PNI); Diagnostic Test: Body Mass Index (BMI); Diagnostic Test: Neutrophil-to-Lymphocyte Ratio (NLR)

Study type: Observational

Funder types: Other

Identifiers

NCT07356219

RC 6.11.2025

Details and patient eligibility

About

Coronary artery bypass grafting (CABG) is a major cardiac surgery associated with risks of serious perioperative complications and mortality. Malnutrition and inflammation are known independent risk factors for poor outcomes in patients with coronary artery disease. This retrospective observational study evaluates the Prognostic Nutritional Index (PNI)-a simple score derived from serum albumin and lymphocyte counts-as an objective measure of nutritional and inflammatory status. The research aims to determine how well preoperative PNI and its postoperative changes can predict complications such as acute kidney injury, myocardial infarction, and sternal wound infections in patients undergoing CABG.

Enrollment: 117 patients

Sex: All

Ages: 25 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent CABG surgery.
• Availability of a signed informed consent form before surgery.

Exclusion criteria

• Other concurrent cardiac surgeries.
• Presence of malignancy or systemic inflammatory disorders.
• Active infection or autoimmune disorders.
• Maintenance on immunosuppressants.
• Liver disease.
• Files with missing data.

Trial design

117 participants in 1 patient group

CABG Patient Cohort.

Description:

Patients who underwent Coronary Artery Bypass Grafting surgery at Benha University Hospital over the preceding five years.

Treatment:

Diagnostic Test: Neutrophil-to-Lymphocyte Ratio (NLR)

Diagnostic Test: Body Mass Index (BMI)

Diagnostic Test: Prognostic Nutritional Index (PNI)