Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival

South Valley University

Status: Completed

Conditions: Cancer, Rectum

Treatments: Other: Surgical resection for cancer rectum

Study type: Observational

Funder types: Other

Identifiers

NCT05667259

SVU-MED-SUR011-4-22-10-464

Details and patient eligibility

About

This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent

Full description

Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent.

Exclusion criteria included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected.

Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes.

Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death

Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.

Enrollment: 229 patients

Sex: All

Ages: 19 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with rectal cancer of stage I-III.
• patients underwent radical resection with curative intent.

Exclusion criteria

• Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
• Early post-operative recurrence, or death within 3 months.