Prognostic Significance of the Lung Immune Prognostic Index (LIPI) in Postoperative Clear Cell Renal Cell Carcinoma: a Multicenter Retrospective Cohort Study

Huazhong University of Science and Technology

Status: Completed

Conditions: ccRCC

Study type: Observational

Funder types: Other

Identifiers

NCT06775574

0361-01

Details and patient eligibility

About

This retrospective study included 704 patients with ccRCC who underwent radical or partial nephrectomy. Patients were stratified into the LIPI good group and the intermediate/poor (int./poor) group based on dNLR (≥ 3) and LDH (≥ 245 U/L) levels. Propensity score matching (PSM) was used to adjust for baseline differences and minimize selection bias. Kaplan-Meier survival curves and Cox regression models were employed to evaluate the impact of LIPI and other clinical factors on recurrence-free survival (RFS) and overall survival (OS).

Enrollment: 704 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Pathologically diagnosed with ccRCC;
2. Underwent radical or partial nephrectomy.

Exclusion criteria

1. presence of concurrent malignancies;
2. missing data or failure to follow-up

Trial design

704 participants in 2 patient groups

Cohort 1

Description:

Patients with dNLR \< 3 and LDH levels below the upper limit of normal

Cohort 2

Description:

Patients with dNLR ≥ 3 and LDH levels above the upper limit of normal