Prognostic Value of Each Codon-specific KRAS Mutation in Colorectal Cancer

Seoul National University

Status

Completed

Conditions

Colorectal Cancer

Treatments

Genetic: Mutation

Study type

Observational

Funder types

Other

Identifiers

NCT05657210

B-2203-742-101

Details and patient eligibility

About

This retrospective study reviewed 3,144 patients who underwent surgery for colorectal cancer. This study was designed to comprehend the clinicopathological characteristics associated with individual codon-specific KRAS mutations in colorectal cancer.

Full description

This study was designed to comprehend the clinicopathological characteristics associated with individual codon-specific KRAS mutations in colorectal cancer including codon 12, 13, and 61. Furthermore, the main objective of this study was to determine whether KRAS codon 13 mutation could serve as a prognostic biomarker of colorectal cancer in a relatively large cohort of subjects. Overall survival (OS) and recurrence-free survival (RFS) were calculated from the date of surgery and compared using the Kaplan-Meier method and log-rank test. For analysis of risk factors for tumor recurrence, Cox proportional hazards regression model was used with the covariance input criterion set as < 0.1. Patients were subdivided based on primary tumor location (colon versus rectum), and MSI status (MSS/MSI-low versus MSI-high).

Enrollment

2,203 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria