Prognostic Value of Heart-type Fatty Acid-Binding Protein (h-FABP) in Acute Pulmonary Embolism

Toulouse University Hospital

Status: Completed

Conditions: Pulmonary Embolism

Treatments: Biological: Dosage de l'h-FABP

Study type: Interventional

Funder types: Other

Identifiers

NCT01326507

0900303

2009-A00441-56 (Other Identifier)

Details and patient eligibility

About

The patients presenting with acute pulmonary embolism and right ventricular dysfunction are at high risk for life-threatening events and must be identified in the emergency department for adequate care and hospital admission. Echocardiography can identify right ventricular dysfunction, but this test is not always available, and echocardiographic criteria of right ventricular dysfunction vary among published studies. The primary purpose of this protocol is to study the prognostic value of a cardiac biomarker, h-FABP (heart-type Fatty Acid-Binding Protein) , to identify in the emergency department the patients presenting with high risk pulmonary embolism. As secondary outcomes, H-FABP results will be compared to other cardiac biomarkers (BNP, troponin) and clinical score performances that have been previously studied to stratify the prognosis of patients with pulmonary embolism in the emergency department.

Enrollment: 165 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with acute pulmonary embolism diagnosed in the emergency departement

Exclusion criteria

• patient under guardianship
• patient without social insurance
• pregnant women
• refusal to sign the consent
• myocardial infarction in the 10 days before pulmonary embolism

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)