Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Klinikum Ludwigshafen

Status: Completed

Conditions: Cardiac Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT00416299

KliLuNTproBNP

Details and patient eligibility

About

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Full description

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Enrollment: 100 patients

Sex: All

Ages: 75+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion criteria

• positive cardiac troponin T test within the week before surgery
• patients undergoing emergent procedures
• patients with preoperative mechanical cardiac support
• patients undergoing hemodialysis