Prognostic Value of Performance Scores in Patients Undergoing Surgery for Upper Tract Urothelial Carcinoma

Kaohsiung Medical University

Status: Completed

Conditions: Carcinoma, Transitional Cell (RENI)

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06305130

KMUHIRB-E(I)-20180214

Details and patient eligibility

About

Aim: to comprehensively evaluate the prognostic value of preoperative ECOG-PS scores and ASA scores in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.

Methods: multicentered cohort study

Full description

Background:

The Eastern Cooperative Oncology Group (ECOG) performance status (PS) score and the American Society of Anesthesiologists (ASA) score are essential tools for the assessment of patients with various malignancies. However, doubts have arisen regarding their prognostic utility due to conflicting findings in limited studies. This study aims to comprehensively evaluate the prognostic value of preoperative ECOG-PS scores and ASA scores in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.

Materials and Methods:

This multicentered cohort study enrolled patients who underwent RNU with curative intentat sixteen institutes in Taiwan from 1988 to 2023. Univariable and multivariable regression analyses were used to determine the impact of ECOG-PS scores and ASA scores on survival outcomes and postoperative complications. Patients were categorized based on ECOG-PS scores (0-1 vs. 2-4) and ASA scores (1-2 vs.3-4) according to prior literature.

Enrollment: 2,515 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients received UTUC surgery and follow-up in sixteen institutions across Taiwan

Exclusion criteria

• Treatment not aimed at curative intent
• Incomplete data

Trial design

2,515 participants in 1 patient group

Primary cohort (only one in this study)

Description:

Patient data were collected from sixteen institutions across Taiwan, encompassing 6005 patients diagnosed with UTUC between 1988 and 2023. The study included all patients who underwent RNU with curative intent. After excluding those with incomplete data, a total of 2515 eligible patients were included in the final analysis.

Treatment:

Other: No intervention