Prognostic Value of Plasma DPP4 Activity in ST-elevation Myocardial Infarction Patients

Chinese PLA General Hospital (301 Hospital)

Status: Completed

Conditions: Coronary Angiography; Dipeptidyl Peptidase 4

Treatments: Diagnostic Test: plasma DPP4 activity

Study type: Observational

Funder types: Other

Identifiers

NCT03046576

DPP4a-MACCE

Details and patient eligibility

About

Increased plasma DPP4 activity (DPP4a) could predict both subclinical and new-onset atherosclerosis, and our previous study has found that the DPP4a was significantly lower in MI patients compared with patients having chest pain or unstable angina alone, and DPP4a is associated with no-reflow and major bleeding events in STEMI patients during hospital stay. As no-reflow phenomenon and major bleeding events independently associates with a worse in-hospital and long-term prognosis. One may speculate that the DPP4a is associated with long-term follow-up adverse cardiovascular events in these patients.The hypothesis was tested in this study.

Enrollment: 625 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• consecutive patients of acute STEMI come to our department,absent of cardiogenic shock, and survival for at least 24 h after PCI treatment.

Exclusion criteria

• patients with cancer, and patients who were taking a DPP4 inhibitoror a glucagon-like peptide-1 (GLP-1) analogue