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An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.
Full description
Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis
Research Type:
Prospective, observational study.
Duration:
October 2016 - October 2017
Associated Medical Centers:
La Paz University Hospital (Madrid), La Princesa Hospital (Madrid), Hospital del Mar (Barcelona), Hospital Clínico de Valladolid and Hospital Clínico de Valencia.
Main Goal:
To measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.
Secondary Goals:
Make a comparison with other biomarkers (procalcitonin, lactic acid, CRP) and clinical severity scales used in standard critical practice (SAPSII, SOFA).
To establish a correlation between the levels of Pro-Adrenomedullin, the time of stay in critical care units, days of mechanical ventilation and mortality.
Variables:
A. Demographics
B. Date of admission to hospital and date of admission to critical care unit unit
C. Clinical data:
D. Intra-abdominal infection episode data
E. Follow-up
F. Pro-adrenomedullin levels at admission, 24 and 72 hours. As well as procalcitonin (PCT), lactic acid and polymerase Chain Reaction (PCR) levels.
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Central trial contact
Ana Maria Montero Feijoo
Data sourced from clinicaltrials.gov
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