Prognostic Value of the AMR Measured After PPCI in STEMI Patients (EARLYMYOAMR)

Henan Institute of Cardiovascular Epidemiology

Status: Active, not recruiting

Conditions: ST Elevation Myocardial Infarction; Coronary Heart Disease

Study type: Observational

Funder types: Other

Identifiers

NCT05653765

HenanICE202201

Details and patient eligibility

About

The goal of this observational study is to learn about in STEMI with Primary PCI Patients. The main questions it aims to answer are:

• To determine the value of AMR in predicting the long-term clinical prognosis of patients with STEMI after PPCI, and to find the best cut-off value.
• Analyze the factors of PPCI affecting AMR and explore the effective measures of PPCI microcirculation protection.

Radiographic images of STEMI receiving primary PCI treatment in several chest pain centers in China will be included. The last image of the infarct-related vessel will be used as a target to calculate its AMR. The relationship between AMR and long-term clinical prognosis was analyzed.

Enrollment: 2,663 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 or older
• Type 1 myocardial infarction
• Receive PPCI

Exclusion criteria

• Failed to identify culprit vessels.
• Structural heart disease with moderate to severe aortic valve or mitral regurgitation and or stenosis that may affect cardiac function
• Dialysis patients with severe renal insufficiency
• Severe and uncontrollable arrhythmia
• Complicated with dilated cardiomyopathy
• Unable to tolerate dual antiplatelet therapy
• Severe and uncontrollable anemia
• Hyperthyroidism
• TIMI blood flow 0-1 grade after PPCI

Trial design

2,663 participants in 2 patient groups

diagnostic cohort/derivation cohort

Description:

The diagnostic/derivation cohort included STEMI patients who underwent PCI within 12 hours and CMR. The optimal AMR cutoff value for diagnosing CMD using CMR was determined by analyzing ROC curves.

prognostic cohort/validation cohort

Description:

The prognostic cohort enrolled STEMI patients who underwent PPCI within 12 hours. All patients were followed up for at least 1 year.