Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Vanderbilt University Medical Center

Status: Completed

Conditions: Normal Pressure Hydrocephalus

Treatments: Other: CSF collection

Study type: Observational

Funder types: Other

Identifiers

NCT00600795

070875

Details and patient eligibility

About

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Full description

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12

The specific aims of this research proposal are to:

1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement.
2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Normal Pressure Hydrocephalus

Exclusion criteria

• Patients not diagnosed with Normal Pressure Hydrocephalus

Trial design

21 participants in 1 patient group

A

Description:

Patients diagnosed with Normal Pressure Hydrocephalus

Treatment:

Other: CSF collection