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Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Vanderbilt University Medical Center logo

Vanderbilt University Medical Center

Status

Completed

Conditions

Normal Pressure Hydrocephalus

Treatments

Other: CSF collection

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Full description

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12

The specific aims of this research proposal are to:

  1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement.
  2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.

Enrollment

21 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Diagnosis of Normal Pressure Hydrocephalus

Exclusion criteria

  • Patients not diagnosed with Normal Pressure Hydrocephalus

Trial design

21 participants in 1 patient group

A
Description:
Patients diagnosed with Normal Pressure Hydrocephalus
Treatment:
Other: CSF collection

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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