Prognostic Value of Tumor Deposits for Patients With Papillary Thyroid Carcinoma

Nanfang Hospital, Southern Medical University

Status: Completed

Conditions: Exploring the Prognostic Value of Tumor Deposits PTC Patients

Treatments: Procedure: surgery

Study type: Observational

Funder types: Other

Identifiers

NCT06051838

NFEC-2023-326

Details and patient eligibility

About

Tumor deposits (TD), nodules in the peritumoral adipose tissue with no architectural residue of lymph node, which is a definition often being confusing to the extranodal extension (ENE), have been described in several malignancies and linked to a worse prognosis. In gastric cancer and colon cancer, TD and ENE should be distinguished and collected separately in 8th AJCC manual. However, in thyroid cancer, TD as a collection variable was absence in both the 8th AJCC manual and the 2015 ATA guideline. This is a study that revealed the presence of TD by reviewing a large number of papillary thyroid carcinoma (PTC) specimens and explored its prognostic value by constructing a nomogram to accurately predict disease-free survival in PTC patients.

Enrollment: 541 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

(1) patients with histopathologically confirmed PTC and sections stored in the pathology department; (2) patients underwent lobectomy or total thyroidectomy and central lymph node dissection with or without lateral neck dissection; (3) patients cooperated to provide follow-up information after surgery.

Exclusion criteria

(1) patients with previous history of neck irradiation or other systematic cancers; (2) patients died of unrelated diseases.

Trial design

541 participants in 2 patient groups

TD cohort

Description:

Tumor deposits (TD) positive group, which was determinded by the pathologists at department of pathology. Any tumor mass, either circumscribed or with irregular contours, devoid of lymph node architecture was identified as a tumor deposit.

Treatment:

Procedure: surgery

Non-TD cohort

Description:

Tumor deposits (TD) negative group, which was determinded by the pathologists at department of pathology. No visiblet umor mass, either circumscribed or with irregular contours, devoid of lymph node architecture in the sections of specimens from these patients.

Treatment:

Procedure: surgery