Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy

Zhejiang University

Status: Enrolling

Conditions: Dilated Cardiomyopathy (DCM)

Treatments: Procedure: coronary angiography

Study type: Observational

Funder types: Other

Identifiers

NCT07293338

2025-0971

Details and patient eligibility

About

The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients with Dilated Cardiomyopathy.

The main question it aims to answer is: Does the coronary microvascular dysfunction impact the outcomes in Patients with Dilated Cardiomyopathy.

Enrollment: 330 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Dilated cardiomyopathy comfirmed by echocardiography: LVDd > 55 mm in men or > 50 mm in women.
• Clinically evident congestive heart failure: Compatible symptoms and signs, and BNP ≥ 35 pg/mL or NT-proBNP ≥ 125 pg/mL, and LV systolic dysfunction defined by LVEF < 45 %.
• Coronary angiography showing stenosis ≤ 50 % in all major epicardial vessels.

Exclusion criteria

• Patients with coronary artery disease, hypertensive heart disease, rheumatic valvular heart disease, myocarditis, and other secondary cardiomyopathies.
• poor angiographic image quality

Trial design

330 participants in 2 patient groups

Coronary microvascular dysfunction

Treatment:

Procedure: coronary angiography

Non-Coronary microvascular dysfunction

Treatment:

Procedure: coronary angiography