Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects

AstraZeneca

Status and phase: Completed; Phase 3

Conditions: Carotid Artery Stenosis; Hypercholesterolemia

Treatments: Drug: Rosuvastatin

Study type: Interventional

Funder types: Industry

Identifiers

NCT00654394

4522IL/0044

D3560C00044

Details and patient eligibility

About

The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fasting blood low density lipoprotein cholesterol level as defined by the protocol
• Diagnosed carotid arterial stenosis

Exclusion criteria

• The use of lipid lowering drugs or dietary supplements after Visit 1.
• Heavy or total occlusion of the carotid artery or recent stroke
• Uncontrolled hypertension, hypothyroidism, alcohol or drug abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 1 patient group

1

Experimental group

Treatment:

Drug: Rosuvastatin