Progressive Strength Training in Spinal Muscular Atrophy

Utah System of Higher Education (USHE)

Status: Completed

Conditions: Muscular Atrophy, Spinal

Treatments: Other: Progressive strength training

Study type: Interventional

Funder types: Other

Identifiers

NCT01233817

39995

Details and patient eligibility

About

The proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. Our pilot study will address 3 aims: (1) Ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with SMA types II and III; (2) Determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with SMA types II and III; and (3) Determine candidate outcome measures.

Enrollment: 12 patients

Sex: All

Ages: 5 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 5-21 years
• diagnosis of SMA type II or III
• at least antigravity strength in elbow flexors
• ability to follow commands and stay on task
• place of residence within a 60-minute or 60-mile drive of the University of Utah

Exclusion criteria

• planned surgery or out-of-town trips during the proposed intervention period
• inability to travel to study center for testing
• neurological diagnosis other than SMA

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Spinal muscular atrophy

Experimental group

Description:

Children and adolescents with diagnosis of SMA type II or III. The intervention group (the only arm/group in this pilot study) receives a home-based, supervised, 12-week progressive strength-training program.

Treatment:

Other: Progressive strength training