Project UPLIFT for Psychogenic Non-Epileptic Seizures (PNES)

Dartmouth Health

Status: Completed

Conditions: Non-Epileptic Seizure; Psychogenic Seizure; Depression; Psychogenic Non-Epileptic Seizure

Treatments: Behavioral: Project UPLIFT

Study type: Interventional

Funder types: Other

Identifiers

NCT03329703

D17161

Details and patient eligibility

About

Developed by researchers from the Centers for Disease Control and Prevention (CDC), Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a group telephone program designed to improve depression for people with epilepsy. Project UPLIFT uses evidence-based approaches of cognitive-behavioral therapy (CBT) and mindfulness-based cognitive therapy to help people manage and prevent symptoms of depression.

For people with psychogenic non-epileptic seizures, there are few treatment options for depression that address the relationship between mood and seizures. There is evidence that mindfulness-based therapy and cognitive therapy are both effective for people with non-epileptic seizures, both in treating depression and reducing seizure frequency. In this study, Project UPLIFT will be offered to patients with psychogenic non-epileptic seizures.

Project UPLIFT is facilitated by a trained clinician to groups of 4-8 patients over the telephone. The group will meet at a regular time, once a week, for 8 consecutive weeks. Participants will be assigned to one of two groups: an immediate-treatment or a waitlist control group which will begin Project UPLIFT 3 months after enrolling in the study.

Full description

Upon enrollment in the study, participants will be randomly assigned to one of two groups: an immediate-treatment group, or a 3-month waitlist control group. Both groups will be given surveys to complete online, and a seizure calendar to keep track of auras, seizures, and events. The immediate-treatment group will be scheduled to start Project UPLIFT with their trained facilitator. Each of the eight weekly sessions will take place at the same day of the week and at the same time, and will last approximately one hour. Participants will have the option of using a fake-name during the telephone calls to conceal their identity during the group telephone calls.

After the 8 weekly sessions, both groups will be given a second set of online surveys to complete individually. At this time, the waitlist control group will be scheduled to start Project UPLIFT with the trained facilitator. After the waitlist group completes the final session of Project UPLIFT, both groups will complete a third and final set of online surveys, thus concluding all study procedures.

Enrollment: 8 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of psychogenic non-epileptic seizures, confirmed by study investigator.
• Literate
• Reliable telephone access

Exclusion criteria

• Dual diagnosis of PNES with epilepsy.
• Presence of serious mental illness that will impair ability to participate.
• Presence of active suicidal ideation at baseline with intention to act.
• Severe mental disability or estimated intelligent quotient (IQ) less than 70.
• No reliable telephone access.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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8 participants in 2 patient groups

Immediate-Treatment

Experimental group

Description:

This group will receive Project UPLIFT immediately after completing surveys.

Treatment:

Behavioral: Project UPLIFT

Waitlist Control

Active Comparator group

Description:

This group will receive Project UPLIFT after waiting approximately 3 months to begin the intervention.

Treatment:

Behavioral: Project UPLIFT