Prokinetic Drugs and Enteral Nutrition (prokinetics)

Universitair Ziekenhuis Brussel

Status: Unknown

Conditions: Enteral Nutrition; Critically Ill

Study type: Observational

Funder types: Other

Identifiers

NCT00916591

2009-012342-23

UZBrussels

Details and patient eligibility

About

The purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.

Full description

Two prokinetic drugs (metoclopramide and erythromycin) will be compared during the administration of enteral nutrition in critically ill patients. We would like to know which one is the most effective in preventing regurgitation and risk of aspiration, which is a common complication of enteral nutritional support. This will be evaluated by measuring gastric residue every six hours.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critically ill patients
• intubated
• mechanically ventilated
• 18 or older age
• enterally fed

Exclusion criteria

• prokinetic drugs before start study
• allergy to study medication
• interactions odf study medication with other drugs
• recent gastro-intestinal surgery
• history of esophagectomy or gastrectomy
• suspicion of gastrointestinal perforation
• myasthenia gravis
• liver dysfunction
• less than 7 days in study
• gastro- or jejunostomy