Prolongation of Pain Free Time by the Use of Dexamethasone in Peripheral Nerve Blockade

Landesklinikum Sankt Polten

Status and phase: Unknown; Phase 4

Conditions: Shoulder Arthroscopy; Interscalene Block; Low Volume Regional Anesthesia; Dexamethasone

Treatments: Drug: Ropivacaine; Drug: Placebo; Drug: Dexamethasone acetate

Study type: Interventional

Funder types: Other

Identifiers

NCT02178449

GS4-EK-2/304-2013 (Other Identifier)

DEXATrial1

Details and patient eligibility

About

The main aim of the study is to investigate the proven effect of dexamethsone on the duration of the interscalene block. The investigators try to define optimal dose and volume for ropivacaine, when used together with dexamethsone. The current literature uses often very high volumes of ropivacain when used together with dexamethasone. The investigators try to research the effect of using dexamethsone together with low volume, high concentration ropivacaine for interscalene blockade. The investigators' hypothesis is that dexamethasone has an positive effect on the pain free after used together with ropivacaine at the scalene block.

Enrollment: 109 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• atroscopy of the shoulder
• repair of the RM

Exclusion criteria

• patient under 18 years
• patient is fertile
• chronic opiat use more than 30mg oxycodone per day
• operations at the shoulder that involves the bone
• usage of cortisone for more than 2 weeks
• risk greater as asa III
• damage to nerves
• neuropathy at the target arm

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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109 participants in 2 patient groups

Verum

Experimental group

Description:

Dexamethasone and Ropivacaine

Treatment:

Drug: Ropivacaine

Drug: Dexamethasone acetate

Placebo

Active Comparator group

Description:

Ropivacaine and Saline

Treatment:

Drug: Ropivacaine

Drug: Placebo