Prolongation of Progesterone Supplementation in Antagonist Cycles and Pregnancy Outcomes

Universitair Ziekenhuis Brussel

Status and phase: Completed; Phase 2; Phase 1

Conditions: Infertility

Treatments: Drug: progesterone

Study type: Interventional

Funder types: Other

Identifiers

NCT01147770

CRG-45

Details and patient eligibility

About

The objective of this study is to evaluate the effect of the prolongation of luteal support on the ongoing pregnancy rate (beyond 12 weeks of gestation )in recFSH/GnRH antagonist cycles.

Enrollment: 200 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age equal or less than 39
• Body mass index between 18-29 kg/m2
• Presence of both ovaries
• Basal hormonal values on day 2 of the cycle
• Embryotransfer day3 or day5
• 1 to 3 cycles

Exclusion criteria

• Endometriosis stage 3
• Polycystic ovarian syndrome
• Frozen or testicular sperm

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 1 patient group

stop progesterone

Experimental group

Treatment:

Drug: progesterone