Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis (Recover-AKI)

Samuel Silver

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Other: Standardized Dialysis and Structured Discontinuation (S2D2); Other: Usual Care

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT04948476

6027699

Details and patient eligibility

About

The overall goal of this study is to evaluate the feasibility of conducting a randomized controlled trial comparing a standardized dialysis strategy versus usual care (dialysis prescription ordered by each patient's primary nephrologist) in patients with AKI-receiving dialysis.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Received ≥2 sessions of any dialysis modality for presumed AKI
• Plans for continued intermittent hemodialysis or sustained low efficiency dialysis treatments

Exclusion criteria

1. Receipt of dialysis for ≥90 days
2. Known baseline estimated glomerular filtration rate (eGFR) <15mL/min/1.73m2
3. Strong clinical suspicion of urinary tract obstruction, rapidly progressive glomerulonephritis (RPGN), vasculitis, thrombotic microangiopathy (TMA), myeloma related cast nephropathy, or acute interstitial nephritis (AIN) as the underlying cause of AKI
4. Receipt of any dialysis prior to the current admission within the past 2 months
5. Kidney transplant within the past 12 months
6. Pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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110 participants in 2 patient groups

Standardized Dialysis and Structured Discontinuation (S2D2)

Experimental group

Description:

Prescription to minimize dialysis-induced ischemia and standardize dialysis discontinuation

Treatment:

Other: Standardized Dialysis and Structured Discontinuation (S2D2)

Usual Care

Active Comparator group

Description:

Dialysis prescription ordered by their primary nephrologist/intensivist.

Treatment:

Other: Usual Care