Pronation in COVID-19 Patients Undergoing Non Invasive Respiratory Support (PRINCESS)

University of Modena and Reggio Emilia

Status: Completed

Conditions: Covid19

Treatments: Behavioral: Prone position

Study type: Observational

Funder types: Other

Identifiers

NCT04649658

UModenaReggio10

Details and patient eligibility

About

Pronation seems feasible and effective in improving blood oxygenation in patients with COVID-19 pneumonia. Data are lacking on the effects of pronation on clinical outcome in this subset of patients.

Enrollment: 93 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Inclusion Criteria

• patients aged ≥18 and < 80 years old
• acute respiratory failure

Exclusion criteria

• endotracheal intubation performed within the first 24 hours from admission,
• ceiling of escalation of intensive care
• do not intubate order as expressed by patient willing or upon clinical judgement
• missing core data at medical record analysis (clinical features at baseline, pronation information, type and time of ventilatory support required, mortality, need for tracheostomy, length of respiratory intensive care unit and hospital stay).

Trial design

93 participants in 2 patient groups

Prone position

Description:

Severe and critical COVID-19 patients undergoing non invasive respiratory support subjected to prone position

Treatment:

Behavioral: Prone position

Standard care

Description:

Severe and critical COVID-19 patients undergoing non invasive respiratory support subjected to standard care