Prone Patient Positioning in Reducing Tumor Motion and Improving Breathing Reproduction in Patients With Lung Cancer Undergoing Radiation Therapy

Virginia Commonwealth University (VCU)

Status: Terminated

Conditions: Lung Cancer

Treatments: Procedure: computed tomography; Radiation: radiation therapy; Procedure: 4-dimensional computed tomography

Study type: Observational

Funder types: Other

Identifiers

NCT01851161

HM12806 (Other Identifier)

MCC-12806

NCI-2013-00848 (Registry Identifier)

Details and patient eligibility

About

This clinical trial studies prone patient positioning in reducing tumor motion and improving breathing reproduction in patients with lung cancer undergoing radiation therapy. Prone patient positioning during radiation therapy may help kill tumor cells without harming normal tissue.

Full description

PRIMARY OBJECTIVES:

I. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion, deformation and volume changes with the respiratory cycle during imaging in prone vs. supine positioning.

II. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion, deformation and volume changes with the respiratory cycle and alterations thereof during a radiotherapy series.

OUTLINE:

Patients undergo one conventional computed tomography (CT) scan and one 4 dimensional CT (4D CT) scan in both supine and prone positioning before undergoing radiation therapy.

Enrollment: 23 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Measurable disease on the planning computed tomography (CT) scan
• Patients with lung cancer visible on fluoroscopic imaging or planning CT who are scheduled to receive external beam radiation treatment will be eligible for this study

Exclusion criteria

• Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies
• Pregnant females

Trial design

23 participants in 1 patient group

Diagnostic (CT and 4D CT in supine and prone positioning)

Description:

Patients undergo conventional CT scan and 4D CT scan in both supine and prone positioning before undergoing radiation therapy.

Treatment:

Procedure: 4-dimensional computed tomography

Radiation: radiation therapy

Procedure: computed tomography