Prone Position and Renal Resistive Index (PRO-KIDNEY)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Prone Position; Acute Kidney Injury; Acute Respiratory Distress Syndrome; Intra-Abdominal Hypertension

Treatments: Other: Prone position

Study type: Interventional

Funder types: Other

Identifiers

NCT04286490

38RC19.265

Details and patient eligibility

About

Patients suffering from Acute Respiratory Distress Syndrome (ARDS) with a prone position (PP) indication will benefit from measurements of renal resistive index, intra-abdominal pressure (IAP), urinary oxygen tension (uPO2) and ventilatory mechanics in supine position (baseline IAP), after 2 hours in PP at the current IAP value, thirty minutes after patients' abdomen suspension in order to resume baseline IAP and after patients' are turned back to supine position.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS patients according to Berlin criteria, intubated, mechanically ventilated
• with PaO₂/FiO₂ < 150 mmHg,
• neuromuscular blockade
• with an indication of PP done by the physician in charge
• possibility to differ PP for one hour
• patients should be hemodynamically stable since at least 4 hours

Exclusion criteria

• Pregnant or breast-feeding women
• legal protection, no social security affiliation
• PP contra-indication
• nasogastric tube contra-indication
• extra corporeal membrane oxygenation
• acute kidney injury at inclusion according to K-DIO criteria, chronic kidney disease defined as an estimated glomerualr filtration rate less than 30 ml/min/1.73m², kidney transplantation, renal artery stenosis, solitary kidney, albuminuria > 1.25 mg/ml
• cardiac arrhythmia
• obesity
• advanced cirrhosis

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Prone position

Experimental group

Treatment:

Other: Prone position