Prone Position for Non-intubated Patients With Acute Respiratory Failure

Karolinska University Hospital

Status: Unknown

Conditions: Respiratory Failure

Treatments: Other: Prone position

Study type: Interventional

Funder types: Other

Identifiers

NCT00526981

2007/733-31/1-4

Details and patient eligibility

About

The study will test the hypothesis that the prone position can be used to reduce the need for intubation and mechanical ventilation in patients with acute respiratory failure.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bilateral pulmonary infiltrates or unilateral infiltrates involving more than one lobe on CXR
• PaO2/FIO2 < 40 kPa
• RR > 25, or attending intensivist considering likelihood of intubation > 50%

Exclusion criteria

• unsuited for the prone position
• fulfilled inclusion criteria for more than 5 days (120 h)
• immunosuppression
• chronic lung disease
• decision of withdrawal or limitation of therapy
• pulmonary infiltrates of cardiac origin
• decreased GCS level
• PaCO2 > 10
• attending intensivist considering the patient unsuited for the prone position
• BMI > 33

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Treatment

Experimental group

Description:

Prone position + all conventional treatment.

Treatment:

Other: Prone position

Control

No Intervention group

Description:

Conventional treatment