Prone Positioning for Invasively Ventilated Patients With COVID-19 Registry (PROVENT-C19)

St. Bortolo Hospital

Status: Unknown

Conditions: COVID-19 Pneumonia

Treatments: Procedure: Prone Position

Study type: Observational

Funder types: Other

Identifiers

NCT04905875

22/21

Details and patient eligibility

About

SARS-CoV-2 infection is characterized mainly by moderate/severe pneumonia associated with progressive endothelial damage and coagulopathy. Acute respiratory failure among COVID-19 occurs in 42% of patients with COVID-19 pneumonia, and 61-81% of patients requiring intensive care . Among the suggested treatments for the management of ARDS patients, prone position (PP) can be used as an adjuvant therapy for improving ventilation in these patients, as recommended in the Surviving Sepsis Campaign COVID-19 guidelines. Nevertheless, no data is currently available on application and feasibility of PP in invasively ventilated patients with COVID-19 on their outcomes.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Laboratory-confirmed COVID-19 infection
• Prone positioning in patients admitted to ICU undergoing invasive Mechanical Ventilation

Exclusion criteria

• Bedsides contraindications to the Prone Positioning and patients in PP but undergoing Non- invasive ventilation should be excluded.

Trial design

1,000 participants in 1 patient group

Critically ill patients with COVID-19

Description:

n centres that obtained IRB approval for this prospective study, all critically ill adult patients (\>18yrs) undergoing PP - that are homogeneous in terms of both clinical and treatment characteristics - will be prospectively observed.

Treatment:

Procedure: Prone Position