Prone Positioning Short-term Effects on Tissue Oxygen Saturation in Critical COVID-19 Patients (PRONECOVID19)

Corporacion Parc Tauli

Status: Enrolling

Conditions: Covid19; ARDS, Human

Study type: Observational

Funder types: Other

Identifiers

NCT04692129

2020/591

Details and patient eligibility

About

The purpose of this study is to monitor short-term changes in tissue oxygen saturation and local blood flow as results of changing from supine to prone position in ARDS COVID-19 patients

Full description

After obtaining consent to participate in the study, the subjects included in the study will undergo a baseline 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline stable StO2 value is obtained, a provocative test, consisting of a transient vascular occlusion, will be performed. The test will allow the obtention of a local metabolic rate, and a StO2 recovery rate after the ischemic stimulus.

Tissue oxygenation measurements will be performed in supine position, immediately before changing to prone positioning, and repeated after 20 minutes of stabilization, once in prone position.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COVID-19 patients admitted in the ICU receiving invasive mechanical ventilation and requiring prone positioning for severe hypoxemia management, as decided by the medical team

Exclusion criteria

• Severe peripheral vasculopathy
• Raynaud's syndrome
• Skin lesions/trauma in upper limbs interfering the placement of the NIRS probe and/or the occlusion tourniquet
• Deep venous thrombosis in the upper limbs