Status and phase
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About
The safety and the efficacy of the Esflurbiprofen Hydrogel Patch will be assessed in comparing with placebo in the treatment of acute pain due to ankle sprain
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Subject is a pregnant, breastfeeding, or lactating female.
Subject has an acute ankle sprain of Grade III as defined by AAOS criteria.
Subject has an ankle fracture as confirmed by X-ray.
Ankle sprain requires surgical treatment.
Subject has experienced recurrent sprains (≥3 sprains of the same joint) or has sprained the affected joint within the last 12 months.
Subject has taken analgesics other than NSAID(s) or acetaminophen for any purpose within 7 days of Screening.
Subject has taken flurbiprofen or naproxen within 24 hours of Screening.
Ankle sprain is treated prior to Screening by ultrasound, physical therapy, or acupuncture.
Subject has used immunomodulators or immunosuppressive therapies (e.g., interferon, oral or parenteral corticosteroids, and cytotoxic drugs) within 4 weeks prior to randomization.
Subject has used any medicated topical agents (e.g., medicated creams or lotions) on the affected ankle within 7 days prior to Screening.
Subject is currently using any other medications that, in the opinion of the Investigator, may exacerbate or mask the anticipated side effects of NSAIDs or interfere with the Investigator's ability to monitor for them (e.g., blood thinners or proton-pump inhibitors).
Subject has non-intact or damaged skin in the area to be treated (e.g., eczema, psoriasis, exudative dermatitis, infected lesion, burn, or wound).
Subject has a history of ulcers, GI bleeding, hypertension, edema, heart failure, or CV disease.
Subject has asthma (except childhood asthma), urticaria, angioedema, or bronchospasm.
a.A subject is eligible for the study if they have had no symptoms of these conditions that required medication in the 5 years prior to Screening.
Subject has a history of any chronic pain disorder.
Subject has coagulation defects.
Subject has a history of severe cardiac, renal, or hepatic impairment within 12 months prior to Screening that, in the opinion of the Investigator, would interfere with the outcome of the study.
Subject has a severe systemic disease (e.g., cancer or severe acute infection).
Subject has a known allergy or hypersensitivity to flurbiprofen, aspirin, other NSAID(s), or any excipient in the IP.
Subject has any systemic or dermatologic disorder that, in the opinion of the Investigator, will interfere with the study results or increase the risk of AEs.
Subject has a history of uncontrolled chronic or acute concomitant disease that, in the Investigator's opinion, would contraindicate study participation or confound interpretation of the results.
Subject has applied ice or compression to the affected ankle within 2 hours prior to Screening.
Subject has a bilateral ankle injury.
Subject has an ipsilateral knee injury. In the opinion of the Investigator, are unsuitable for inclusion in the study.
Primary purpose
Allocation
Interventional model
Masking
6 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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