Properties of Glass Ionomer Cements Associated With Chlorhexidine or Doxycycline

Aline R F de Castilho

Status and phase: Completed; Phase 2

Conditions: Dental Caries

Treatments: Other: Indirect pulp treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT02168374

PGICACD

FAPESP (Other Identifier)

Details and patient eligibility

About

This study assessed the clinical performance of a resin-modified glass ionomer cement containing different concentrations of chlorhexidine digluconate and doxycycline hyclate.

Full description

This study aimed to evaluate the in vivo microbiologic action of the best concentration of chlorhexidine and doxycycline associated with the resin-modified glass ionomer cement applied on remaining dentine after indirect pulp treatment.

Enrollment: 18 patients

Sex: All

Ages: 4 to 8 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• an active deep carious lesion at the internal half of the dentine thickness of a primary molar that had not been previously restored and that involved the occlusal or occlusoproximal surface;
• the absence of signs of irreversible damage to the pulp
• the absence of radiolucencies at the interradicular or periapical region or thickening of the periodontal spaces, absence of internal and external root resorption, absence of calcification of the pulp tissue
• children presenting no systemic disease or those not using medications.

Exclusion criteria

• presence of signs of irreversible damage to the pulp
• children presenting systemic disease or those using medications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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18 participants in 3 patient groups, including a placebo group

Chlorhexidine - CHX

Experimental group

Description:

Deciduous teeth were filled with GIC containing 1.25% chlorhexidine.

Treatment:

Other: Indirect pulp treatment

Doxycycline - DOX

Experimental group

Description:

Deciduous teeth were filled with GIC containing 4.5% doxycycline.

Treatment:

Other: Indirect pulp treatment

Glass ionomer cement - GIC

Placebo Comparator group

Description:

Deciduous teeth were filled with GIC without chlorhexidine or doxycycline.

Treatment:

Other: Indirect pulp treatment