Prophylactic Antibiotic in Treatment of Fingertip Amputation

HaEmek Medical Center, Israel

Status: Completed

Conditions: Infection Rate After Fingertip Amputation

Treatments: Drug: Cephazolin

Study type: Interventional

Funder types: Other

Identifiers

NCT02077400

0115-09-EMC

Details and patient eligibility

About

Fingertip amputation is a common injury. Considerable controversy exists as to whether prophylactic antibiotics are necessary for this injury. The investigators goal was to compare the rate of infections among subgroups with and without prophylactic antibiotic treatment. The study hypothesis was that infection rates were similar in the two groups.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• fingertip amputation with bone exposed

Exclusion criteria

• under the age of 18 years
• if the patient had diabetes
• oncological disorder
• immune deficiency
• bleeding disorder
• used steroids regularly
• presented with a grossly contaminated wound or other injury requiring antibiotic treatment
• were currently taking antibiotics, or had a previous allergic reaction to cephalosporins.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

no antibiotic

No Intervention group

Cephazolin

Active Comparator group

Description:

cefazoline

Treatment:

Drug: Cephazolin