Prophylactic Antibiotics in the Endoscopic Secondary Prevention of Cirrhotic Patients With Varices: a Retrospective Study

Zhejiang University

Status: Completed

Conditions: Cirrhosis, Liver Hypertension, Portal Variceal Hemorrhage

Treatments: Drug: Prophylactic Antibiotics; Other: No use of prophylactic antibiotics

Study type: Observational

Funder types: Other

Identifiers

NCT07616466

2026-0728

Details and patient eligibility

About

Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this retrospective study, we are aimed to evaluate whether prophylactic antibiotics confer advantages in the endoscopic secondary prevention of cirrhotic patients with gastroesophageal varices.

Enrollment: 480 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhotic patients with a history of gastroesophageal variceal bleeding who were readmitted for elective endoscopic treatment.

Exclusion criteria

• (1) Age < 18 or ≥ 81 years; (2) Allergy to cephalosporin; (3) Agranulocytosis (neutrophil count < 0.5 × 10^9/L); (4) Massive ascites; and (5) Signs of bacteria infection.

Withdraw Criteria:（1）Transferred to other department for additional treatment after the endoscopic operation (Surgical department for malignant tumor, Interventional radiology department for splenic embolism or transjugular intrahepatic portosystemic shunt, etc.). （2）Lost to follow-up

Trial design

480 participants in 2 patient groups

No prophylactic antibiotics

Description:

No use of prophylactic antibiotics before endoscopic therapy

Treatment:

Other: No use of prophylactic antibiotics

Prophylactic antibiotics

Description:

Intravenous infusion of 2.0g ceftriaxone before endoscopic therapy

Treatment:

Drug: Prophylactic Antibiotics