Prophylactic Anticoagulation for Preventing Deep Vein Thrombosis After Total Hip Arthroplasty

JIANG Qing

Status and phase: Completed; Phase 3; Phase 2

Conditions: Deep Vein Thrombosis

Treatments: Other: prophylactic anticoagulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01446887

NJDVTS

Details and patient eligibility

About

Deep vein thrombosis (DVT) remains a life-threatening complication of arthroplasty. It remains controversial for anticoagulation strategies after total hip arthroplasty (THA). A randomized double-blind study was conducted to determine whether prophylactic anticoagulation was efficient reduce DVT after THA. subjects who underwent uncemented THA were assigned to prophylactic anticoagulation group or non- prophylactic anticoagulation group. Patients were followed up 3 months later after surgery. DVT was tested by contrast venography. Investigator also used logistic regression analysis with variable selection for obtaining the prediction model of DVT. DVT after THA was affected by personal (age) and clinical factors (mechanical compression, duration of surgery). THA with short duration of surgery did not require prophylactic anticoagulation.

Sex: All

Ages: 35 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary total hip arthroplasty

Exclusion criteria

• Revision hip replacement, total knee replacement, revision knee replacement, semi-hip replacement and cemented THR were excluded.
• Coagulation related disease and cancer were excluded either.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups

non-prophylactic anticoagulation

No Intervention group

Description:

without prophylactic anticoagulation

prophylactic anticoagulation

Experimental group

Description:

prophylactic anticoagulation by rivaroxaban

Treatment:

Other: prophylactic anticoagulation