Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

Yonsei University

Status: Completed

Conditions: Laparoscopic Marsupialization of Renal Cyst

Treatments: Drug: Ondansetron; Drug: Palonosetron; Drug: Normal saline inj; Drug: Ramosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT01169805

4-2010-0176

Details and patient eligibility

About

The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.

Enrollment: 105 patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I or II
• Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy
• Patients who want a patient-controlled IV analgesia (IV-PCA)

Exclusion criteria

• History of allergy or hypersensitivity to 5-HT3 antagonist
• History of severe postoperative nausea/vomiting
• Prolonged QT interval on preoperative EKG
• Hypokalemia, Hypomagnesemia
• Intestinal obstruction
• Pregnant female or breast feeding mother

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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105 participants in 4 patient groups, including a placebo group

ONSERAN

Experimental group

Treatment:

Drug: Ondansetron

NASEA

Experimental group

Treatment:

Drug: Ramosetron

ALOXI

Experimental group

Treatment:

Drug: Palonosetron

normal saline

Placebo Comparator group

Treatment:

Drug: Normal saline inj