Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension

Cairo University (CU)

Status: Completed

Conditions: Post Induction Hypotension; Sepsis

Treatments: Drug: Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction

Study type: Interventional

Funder types: Other

Identifiers

NCT07022730

noradrenaline and PIH

Details and patient eligibility

About

researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension

Full description

If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension

Enrollment: 80 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients with sepsis undergoing source control surgery.

Exclusion criteria

• Patient refusal
• Patient with cardiac pathology ( ischemic heart disease or heart failure)
• Preoperative hemodynamic instability (defined as MAP < 65 mmHg)
• Rapid sequence induction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Noradrenaline

Active Comparator group

Description:

Noradrenaline will be infused at a fixed rate of 0.2 mic/kg/min at 5 minutes before induction

Treatment:

Drug: Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction

Control

No Intervention group

Description:

Patients will receive normal saline