Prophylaxis With Intranasal Mupirocin for Prevention of S. Aureus Infections

University Hospital Muenster

Status and phase

Completed

Phase 4

Conditions

Cross Infection

Staphylococcal Infections

Treatments

Drug: Mupirocin

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00156377

4710F-186

Details and patient eligibility

About

In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent Staphylococcus aureus infection, a prospective randomized trial was performed particularly including patients with predisposing risk factors for S. aureus infections.

Full description

In a past study, we showed that there is a strong correlation between strains colonizing the anterior nares, strains isolated from the presumed foci of infection, and strains isolated from blood in patients with Staphylococcus aureus bacteremia. These results suggested that a substantial proportion of cases of systemic S. aureus infections appear to be of endogenous origin and that eradication of nasal colonization should be the chief strategy for reducing the incidence of hospital-acquired S. aureus infections.

In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent S. aureus infection, a prospective randomized trial was performed particularly including patients with predisposing risk factors for S. aureus infections. All patients admitted to selected units in clinics for anaesthesiology, hemato-oncology, cardiac surgery, and orthopedics at the University Hospital of Muenster were regularly screened for nasal carriage, i.e. at admission and, subsequently, on a weekly basis. S. aureus carrying patients were prospectively randomized, to be either treated with mupirocin for 5 days, or left untreated. Patients infected with S. aureus at admission and patients detected to be MRSA carrier were excluded from randomization.

Patients were regularly seen during the course of their hospital stay and predisposing/conditional risk factors were systematically documented. In both groups (untreated patients and patients with mupirocin prophylaxis), all nosocomial infections were documented according to CDC guidelines. If infected, specimens were taken for microbiological diagnosis. All S. aureus isolates (from the anterior nares as well as from the focus of infection) were collected and were genotyped.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients admitted to selected units in clinics for anaesthesiology, hemato-oncology, cardiac surgery, and orthopedics at the University Hospital of Muenster (following information on the study and agreement of the patient).

Exclusion criteria

Patients infected with S. aureus at admission
S. aureus infection within 48 hours following admission
Patients detected to be carrier of Methicillin-resistant S. aureus
Hospital stay shorter than 72 hours
Patients with anatomic abnormalities in the anterior nares
Allergy or hypersensitivity to mupirocin or other substances of the nasal ointment
Persons younger than 18 years
Known pregnancy
Persons with psychiatric diseases
Persons with limited contractual capability and judiciousness