Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

Mansoura University

Status: Unknown

Conditions: Endoscopic Sinus Surgery

Treatments: Drug: Magnesium Sulfate infusion; Drug: Atracurium; Drug: Lidocaine; Drug: Fentanyl; Procedure: Mechanical Ventilation; Drug: Propofol infusion; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04078659

MS ∕18.08.247

Details and patient eligibility

About

Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.

Propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property.

Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking N-type calcium channel at the nerve ending beside acting as a vasodilator.

The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium Sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

Full description

The aim of the work to compare the efficacy of propofol and magnesium sulfate to control blood pressure during endoscopic sinus surgery and the resultant effects on the quality of the surgical field including bleeding and visibility.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists Physical Classes I or II

Exclusion criteria

• Patients refusal
• Patients with hypersensitivity for any drug used in the study including magnesium, propofol or isoflurane
• Patients receiving magnesium sulfate supplementation
• Patients receiving drugs known to have significant interaction.
• Patients with ischemic heart disease
• Patients with heart defects
• Patients with significant heart failure
• Patients with increased intracranial pressure.
• Patients with systemic hypertension

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Propofol infusion

Experimental group

Description:

Patients received intravenous Propofol infusion

Treatment:

Drug: Lidocaine

Drug: Atracurium

Drug: Fentanyl

Procedure: Mechanical Ventilation

Drug: Propofol

Drug: Propofol infusion

Magnesium Sulfate infusion

Experimental group

Description:

Patients received intravenous Magnesium Sulfate infusion

Treatment:

Drug: Lidocaine

Drug: Magnesium Sulfate infusion

Drug: Atracurium

Drug: Fentanyl

Procedure: Mechanical Ventilation

Drug: Propofol