Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury (PROSACC)

Uppsala University

Status: Active, not recruiting

Conditions: Acute Kidney Injury; Cancer Colorectal

Treatments: Drug: Anesthesia Agent

Study type: Observational

Funder types: Other

Identifiers

NCT05585866

PROSACC2021

Details and patient eligibility

About

The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury.

The main questions it aims to answer are:

• is there a difference in acute kidney injury incidence in the two anesthetic modalities?
• is there a difference in plasma creatinine between the two anesthetic modalities?
• are there any patient characteristics or intraoperative factors that effect the incidence of acute kidney injury in either anesthetic modality?

The study will analyze data from the CAN clinical trial database. (Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia, NCT01975064)

Enrollment: 4,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• colorectal surgery and participant in the CAN trial

Exclusion criteria

• missing blood samples

Trial design

4,000 participants in 2 patient groups

Sevoflurane

Description:

The group of patients which received sevoflurane as randomized anesthetic modality.

Treatment:

Drug: Anesthesia Agent

Propofol

Description:

The group of patients which received propofol as randomized anesthetic modality.

Treatment:

Drug: Anesthesia Agent