Propofol Effects on Mitral Valve Annular Velocity

Konkuk University Medical Center

Status and phase: Completed; Phase 4

Conditions: Coronary Artery Disease; Valvular Heart Disease

Treatments: Drug: Propofol 1.0mcg; Drug: Propofol 2.0mcg; Drug: Propofol 3.0mcg

Study type: Interventional

Funder types: Other

Identifiers

NCT01826149

KUH1160053

Details and patient eligibility

About

The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging

Full description

The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.

Enrollment: 40 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients undergoing cardiac surgery

Exclusion criteria

low ejection fraction < 50% on transthoracic echocardiography atrial fibrillation pacemaker pericardial and infiltrative myocardial disease mitral annular calcification, surgical rings, prosthetic mitral valve lateral left ventricular wall motion abnormality oesophageal abnormality history of extensive radiation to the mediastinum upper gastrointestinal bleeding

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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40 participants in 3 patient groups

Propofol 1.0mcg

Experimental group

Description:

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 1.0mcg/ml using target controlled infusion.

Treatment:

Drug: Propofol 1.0mcg

Propofol 2.0mcg

Experimental group

Description:

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 2.0mcg/ml using target controlled infusion.

Treatment:

Drug: Propofol 2.0mcg

Propofol 3.0mcg

Experimental group

Description:

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 3.0mcg/ml using target controlled infusion.

Treatment:

Drug: Propofol 3.0mcg