Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

Chaudhry Pervaiz Elahi Institute of Cardiology

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Drug: Midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT05290324

CPEIC22

Details and patient eligibility

About

Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.

Full description

Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.

Enrollment: 60 patients

Sex: All

Ages: 20 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of American Society of Anesthesiologists (ASA) III who were selected for coronary artery bypass graft surgery.

Exclusion criteria

• History of any psychiatric disease.
• Using antidepressants
• Alcohol abusers
• Obese
• Pregnant women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups

MIdazolam Group

Experimental group

Description:

Following surgery Immediately after shifting in ICU, midazolam infusion were administered as 0.25 mg/kg/min.

Treatment:

Drug: Midazolam

Propofol Group

No Intervention group

Description:

Following surgery after Immediately shifting in ICU propofol infusion was started at 10µg/kg/min.