Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Hennepin Healthcare

Status and phase: Completed; Phase 4

Conditions: Sedation

Treatments: Drug: propofol; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT00997321

MMRF062661

Details and patient eligibility

About

This study is a clinical trial of moderate sedation with propofol versus moderate sedation with ketamine for procedural sedation in the Emergency Department.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who require moderate procedural sedation with propofol in the ED

Exclusion criteria

• age > 17 years
• pregnant
• intoxicated
• cannot give informed consent
• allergy to ketamine or propofol
• patient will require deep procedural sedation
• ASA physical status score > 2

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Propofol

Active Comparator group

Description:

propofol 1 milligram per kilogram intravenous bolus followed by 0.5 millligrams per kilogram as needed for mooderate procedural sedation

Treatment:

Drug: propofol

Ketamine

Active Comparator group

Description:

ketamine 1 milligram per kilogram followed by 0.5 millgram per kilogram as needed for moderate procedural sedation

Treatment:

Drug: Ketamine